Information on New Cell Remedy for LBCL Encouraging, Analyst Says

December 19, 2022 ( Newswire) The biopharma behind the investigational therapy plans to advance it right into a probably pivotal scientific program subsequent 12 months, famous a BTIG report.

Adicet Bio Inc. (ACET:NASDAQ) introduced “encouraging” information from its ongoing Part 1 trial evaluating the corporate’s lead therapeutic ADI-001, its chimeric antigen receptor (CAR) T-cell remedy, in massive B-cell lymphoma, reported BTIG analyst Justin Zelin in a Dec. 12 analysis be aware. The information replace passed off on the American Society of Hematology’s annual assembly on Dec. 10 to 13.

The examine confirmed Adicet’s anti-CD20, allogeneic, gamma delta CAR T-cell remedy to have a six-month full response price that’s similar to that of autologous CAR-T remedy in addition to key security benefits, Zelin highlighted.

“An off-the-shelf, allogeneic remedy with [a] differentiated and well-tolerated security profile carries a robust worth proposition on this setting,” Zelin commented.

Subsequent Steps and Potential Catalysts

Massachusetts-based Adicet will proceed enrolling sufferers within the examine to achieve additional insights into sturdiness and the really useful Part 2 dose choice, famous Zelin. The seemingly selections are two infusions of DL3 (300 million cells) with one lymphodepletion or one dose of DL4 (1 billion cells).

Additionally, in about Q2/23, Adicet plans to maneuver ADI-001 right into a probably pivotal scientific program, Zelin famous.

This would come with two research, one in post-CAR-T massive B cell lymphoma sufferers and the opposite in earlier-line massive B cell lymphoma sufferers. Discussions are deliberate with the U.S. Meals and Drug Administration and the European Medicines Company concerning the regulatory path ahead for this program.

“We sit up for scientific and regulatory updates from the corporate subsequent 12 months,” wrote Zelin.

Constructive Efficacy and Security

The up to date Part 1 information indicated a possible efficacy sign for ADI-001 in post-CAR-T massive B cell lymphoma sufferers, Zelin wrote. In any respect ADI-001 dose ranges, sufferers confirmed a 75% general response price and a 69% full response price. 5 sufferers, who beforehand relapsed on anti-CD19 autologous CAR-T remedy, had 100% general response and full response charges.

Zelin relayed that Dr. Sattva Neelapu, within the Division of Lymphoma-Myeloma on the MD Anderson Most cancers Middle, “expressed his pleasure of the entire response price in closely pretreated sufferers with few various therapy choices (estimated median progression-free survival is about two months), particularly in post-CAR-T massive B cell lymphoma sufferers. Dr. Neelapu notes a roughly 30% length of response at six months can be considered favorably.”

By way of security, on the DL3+ dose (DL3: 300 million CAR+ cells; DL4: 1 billion CAR+ cells), at which the entire response price was 86%, there have been no grade 3 or increased negative effects, together with cytokine launch syndrome, immune effector cell related neurotoxicity, graft versus host illness or dose-limiting toxicities. Infections have been minimal regardless of enhanced lymphodepletion being employed.

The “capacity to soundly redose with a single lymphodepletion routine helps outpatient-community dosing as key benefits for Adicet’s allogeneic cell remedy,” Zelin added.

BTIG has a Purchase ranking and a US$34 per share value goal on Adicet, which is at the moment buying and selling at about US$19.88 per share.


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BTIG Analysis, Adicet Bio Inc., December 12, 2022

Analyst Certification: I, Justin Zelin, hereby certify that the views concerning the firms and securities mentioned on this report are precisely expressed and that I’ve not obtained and won’t obtain direct or oblique compensation in change for expressing particular suggestions or views on this report.

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